This implies of course that you play a necromancer. Both methods of course rely on the fact that act bosses have bonus damage against invocations which works against them.
The usual way to kill bosses fast is to summon a golem and use Iron Maiden; that works fine in Normal and somewhat in Nightmare, but it loses its effectiveness in Hell.
There is an even better, and damaging, method, for Act 4 normal and up: combine Thorns with Amplify damage. Not only does it work better, but it also works even better in Hell difficulty (if you know how AD works, you'll know why).
In order to get Thorns before Nightmare difficulty, have an Act 1 mercenary equipped with Edge, which provides a level 15 Thorns aura. Summon your golem of choice (I prefer clay golem, it's cheap and very tanky), AD the boss, see his hit points drop quite a lot from one single hit of his...
When reaching nightmare act 2 you can swap for a Combat merc which does provide Thorns as well, although at a lesser level (Thorns is capped at level 15, and the merc has to be level 75+ for that... Ouch).
The ideal is of course to wear Bramble, since it provides a minimum thorns level of 16, up to 21.
Oh, and this of course works for the Ancients too.
This post was edited by notfge on Aug 3 2021 02:42am