tbh I suggest softcore for this league
anyway a few tips that might help you survive:
JANUS is a bitch, avoid him if you can. Afaik he deals phys damage which cant be evaded/dodged/blocked. Not sure if spell dodge or spell block work.
the spiky attack from the ground can offscreen
try to keep him in jail, unranked or remove him from the syndicate
IT THAT FLED
heavy chaos damage spells, can offscreen. Get chaos res (also very useful for incursion chaos spitters so very good for this league)
try to keep your intervention with just 1-2 syndicate members and no allies (no green ropes) so you don't get insta gibbed suddenly
fortification spawns super strong mobs until you destroy one of the doors so try to kill the door asap before the adds overwhelm you