Quote (Fault @ 10 Jun 2011 14:56)
Hmm, click on the signature, set that as the desired number (1 or 2). Then click on your notes, set that as the other number (1 or 2). Then click on update settings and then save settings.
I had issues with this the other day

Unless if you're talking about the actual content in the signature and notes. If your information isn't saving, then I'm not sure.

It might be worth trying to clear your cache if you haven't already.
The information itself is not saving.
Quote (iDGames @ 10 Jun 2011 14:59)
In the case that Fault's explanation does not help:
You say you "hit the edit button again to save it". This might be the problem, since you actually hit no button twice.
To edit your notes or signature, you first need to press the
edit button:
http://forums.d2jsp.org/images/edit.gifWhen you are finished editing, press the
edit signature / edit notes button below the text box.
When I hit the edit button, it reloads my profile page, without setting my signature.