the only damage that matters is the stuff that can actually kill you
de seis mobs, stygian dolls, black souls, dark archers, etc
There is plenty of reason to go for max block / max dr / tgods / wisp / dwarf / hotspurs if you want the tankiest pvm build possible that won't die when you disconnect
ie someone going for 99 HC
only regarded people play hc, with shitty blizzard server I'll never play hc unless its single player. I'll take my chances as its 75% encounter rate vs 25%, at the end of the day its just math.