In the middle of games and whatever, my HoN crashes, does this happen to anybody else?

could be a ram issue

get more ram
test your ram
close other programs while playing hon
lower graphics settings
reinstall hon
uninstall mods

not in that order

8GB RAM

All works/reads properly
I'll try closing all other programs, but that shouldn't really do anything.
My graphics are fine (Nvidia GT555M)
I'll try to reinstall hon if closing all programs works
No mods

try messing around with some of the setting (disabling some)

Works fine for me.