So I like to save the beefed up maps (bosses, corruption, delerium, etc) that are in tower clusters for later but ill run the ones that aren't in proximity to multiple towers to help gear up. You can activate towers now, and just not run the maps until t13+ and the buffs from towers will still be there afaik (I could be wrong about this so check elsewhere to make sure). That said, I don't think there will be a shortage of nodes on the map. I'm not sure if anyone has found the end of the map or if there even is one.