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New CRISPR cancer treatment tested in humans for first time

https://www.freethink.com/health/crispr-cancer-treatment

If the antivax people think the covid-19 vaccine is "bad" then whoa boy are they going "love" this therapy.

CRISPR is actually a sequence of genetic code from a virus that is being used to modify and "reprogram" human immune system cells to fight cancer.

This is obviously a massive break through in fighting cancer, but I was wondering what the anti-vax people who post here had to say about it.

Are you going to allow doctors to reprogram your body so that you can live?

Or just slowly die while you complain about it on social media?

I am a non anti vax conservative.

Real question, no bias:

So, if you were diagnosed with cancer, and the doctor said "well, we're going to have to reprogram your immune system using an experimental therapy" would you do it or not?

I would personally do it.

there needs to be at least 3 phases of trials.
But if i only have 1 or 2 months then Yes I will do it . Because if it works, good for me .

I don't feel like VPNing into work to read the underlying paper, but did they do anything to eliminate any off-target cuts from crispr? I think if I was dying of cancer I'd try this but it's still risky.

Ok. Thank you for the response.



From what I understand:

The immune system cells they rerprogrammed were outside of the body, which should eliminate many of the problems with CRISPR.

I don't know if that answers your question.

I get why they did it ex-vivo and reimplanted the cells, but you can still get random off-target cuts with CRISPR across the genome leading to unpredictable effects once they reintroduce it in the body. What they're proposing will also be fairly expensive but its a cool paper. Each treatment is going to end up being an N=1 since they're sequencing tumors to find unique mutations to target.

Edit: Also looking at the abstract/author interviews, the treatment didn't work. They claim they need higher doses so if there's any chance of complications/off-target effects you'll see it there. They likely picked a dose in line with some theoretical MABEL level since this is so novel.

Also it isn't a vaccine, its just a treatment since you need to have cancer first before they can design their CRISPR guides

This post was edited by Sioux on Nov 20 2022 01:21pm

First step towards immortality.