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Nov 23 2020 06:33pm
Quote (Knoppie @ 24 Nov 2020 00:00)
Except for the "3rd world" where they've had an ebola outbreak, which needed -70C coolers. Africa is not one country ;)
And India does have a cold chain network, that dealt with the rotavirus. I'm not sure if that needed -70 of 2-8 C. But it looks like to just needs a small upgrade to distribute from the AstraZeneca factory in India. Imo that looks promising and I am a bit thrilled that AstraZeneca can make 3bil vaccines (for comparison: 1.3 for Pfizer/BioNTech and 500mil for Moderna) in 2021.


The ebola outbreaks were very local, and were dealt with in significant parts by WHO doctors.
The rotavirus vaccines can be stoored in a fridge at 2-8°C, that's far easier.




I think you all underestimate the logistical challenge of deploying a vaccine to literally billions of people within a few couple of months. Customary fridges being sufficient for the transport and storage clearly makes a huge difference.
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Nov 23 2020 06:53pm
Just let it end.
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Nov 24 2020 08:33am
That other company with 70% is amazing news, shouldn’t be down played at all. It’s a regulation vaccine, non mrna based aka traditional methodology so easier to implement in a lot of
Societies that don’t have adequate infrastructure.

Don’t forget 1 month ago we all would have been sucking dick for a 70% effective vaccine.

Word on the street is the pfizer/moderna vaccines will be getting rolled out to immunocompromised and health care workers by December. That’s way ahead of any schedule I would have predicted, but it hasn’t happened yet so let’s see
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Nov 24 2020 09:24am
Quote (Bazi @ Nov 24 2020 09:33am)
That other company with 70% is amazing news, shouldn’t be down played at all. It’s a regulation vaccine, non mrna based aka traditional methodology so easier to implement in a lot of
Societies that don’t have adequate infrastructure.

Don’t forget 1 month ago we all would have been sucking dick for a 70% effective vaccine.

Word on the street is the pfizer/moderna vaccines will be getting rolled out to immunocompromised and health care workers by December. That’s way ahead of any schedule I would have predicted, but it hasn’t happened yet so let’s see


90% with 2 shots is it not??? :O still ya hope we can get behind lockdowns before 2021 summer... shit so fucking stressful :( be happy even before spring but hopes not high for that

This post was edited by GarryGarry on Nov 24 2020 09:24am
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Nov 24 2020 09:33am
Quote (GarryGarry @ 24 Nov 2020 16:24)
90% with 2 shots is it not??? :O still ya hope we can get behind lockdowns before 2021 summer... shit so fucking stressful :( be happy even before spring but hopes not high for that


I've read that the 70% figure for the AstraZeneca vaccine is just an average. Two shots, one month apart and with only half the dose on the first shot, is reported to lead to 90% efficiency. By contrast, if you apply two full doses (again one month apart), protection is only at 62%. The AstraZeneca folks say they're as puzzled by this outcome as we are, and will look into it over the coming months. Based on the unequal frequency of these two dosages in their study, these protection rates then averaged out to 70%.

So, tldr: it's not clear yet if a 90% efficiency can be replicated, but chances are that their vaccine can get higher than 70.

This post was edited by Black XistenZ on Nov 24 2020 09:33am
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Nov 24 2020 09:42am
Quote (Bazi @ Nov 24 2020 08:33am)
That other company with 70% is amazing news, shouldn’t be down played at all. It’s a regulation vaccine, non mrna based aka traditional methodology so easier to implement in a lot of
Societies that don’t have adequate infrastructure.

Don’t forget 1 month ago we all would have been sucking dick for a 70% effective vaccine.

Word on the street is the pfizer/moderna vaccines will be getting rolled out to immunocompromised and health care workers by December. That’s way ahead of any schedule I would have predicted, but it hasn’t happened yet so let’s see


Quote (Black XistenZ @ Nov 24 2020 09:33am)
I've read that the 70% figure for the AstraZeneca vaccine is just an average. Two shots, one month apart and with only half the dose on the first shot, is reported to lead to 90% efficiency. By contrast, if you apply two full doses (again one month apart), protection is only at 62%. The AstraZeneca folks say they're as puzzled by this outcome as we are, and will look into it over the coming months. Based on the unequal frequency of these two dosages in their study, these protection rates then averaged out to 70%.

So, tldr: it's not clear yet if a 90% efficiency can be replicated, but chances are that their vaccine can get higher than 70.


I got this info from a friend who has been following the trials VERY closely, and is participating in the Pfizer trial:

Quote
So why would LESS vaccine be MORE effective?

The prevailing theory so far is that it's because this vaccine uses a weakened adenovirus vector -- basically, just a different kind of virus -- which is manipulated to create the SARS-CoV-2 spike protein, which in turn causes the body to learn to fight that protein.

When the first dose is a full dose, the body gets really good at fighting the adenovirus vector -- even though it doesn't have to -- which makes the second vaccine less effective, because the body attacks the adenovirus before the vaccine has a chance to produce the spike protein. Fascinating stuff.
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Nov 24 2020 09:44am
Quote (Black XistenZ @ Nov 24 2020 10:33am)
I've read that the 70% figure for the AstraZeneca vaccine is just an average. Two shots, one month apart and with only half the dose on the first shot, is reported to lead to 90% efficiency. By contrast, if you apply two full doses (again one month apart), protection is only at 62%. The AstraZeneca folks say they're as puzzled by this outcome as we are, and will look into it over the coming months. Based on the unequal frequency of these two dosages in their study, these protection rates then averaged out to 70%.

So, tldr: it's not clear yet if a 90% efficiency can be replicated, but chances are that their vaccine can get higher than 70.


oh well still good 70% for this vaccine cuz easier and cheaper but still have other vaccines coming out :) so hopefully more good news in next few months with them as well
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Nov 24 2020 10:38am
Quote (Surfpunk @ 24 Nov 2020 16:42)
I got this info from a friend who has been following the trials VERY closely, and is participating in the Pfizer trial:


This explanation makes a lot of sense. Fascinating stuff.

In the long run, all the focus and resources being put into vaccination techniques because of covid will lead to huge progress in the field, similar to how the apollo program spurred various technological advances.
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Nov 24 2020 11:38am
WARP SPEED!

Quote (Black XistenZ @ Nov 23 2020 07:33pm)
The ebola outbreaks were very local, and were dealt with in significant parts by WHO doctors.
The rotavirus vaccines can be stoored in a fridge at 2-8°C, that's far easier.




I think you all underestimate the logistical challenge of deploying a vaccine to literally billions of people within a few couple of months. Customary fridges being sufficient for the transport and storage clearly makes a huge difference.


I think only 30% of the population genuinely needs the vaccine.

This post was edited by EndlessSky on Nov 24 2020 11:40am
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Nov 24 2020 11:59am
Quote (Black XistenZ @ Nov 23 2020 10:16pm)
Nope, sorry. Was too busy watching my hometown club Bayern Munich win 5 titles in one season. :P



But let's cut the off-topic...


That's the Blundesliga though

Put me as a striker in the Blundesliga I'll score 15 a season and I'm not even good.

This post was edited by dro94 on Nov 24 2020 12:00pm
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