Quote (Kayeto @ Apr 21 2020 09:52pm)

https://news.sky.com/story/coronavirus-deaths-41-higher-than-official-figures-ons-11976357


Large numbers of deaths in UK nursing homes haven't been added to the death toll. Remains to be seen how exactly they will decide to count those deaths.

Quote (Kayeto @ Apr 21 2020 11:08pm)

The motivation for creating one wasn't there since the disease was quashed by external methods. Unfortunate because the research into Sars-CoV-1 that would have been done might have included some useful lessons in the race to develop a vaccine for Sars-CoV-2.

Quote (ofthevoid @ Apr 21 2020 01:07pm)

A rare successful meme from the left, nice.

Quote (Djunior @ 21 Apr 2020 23:13)

SARS was more deadly than COVID-19, they surely had a reason to develop a vaccine. And they did or better said they tried.

Quote (Black XistenZ @ Apr 21 2020 11:20pm)

SARS had a higher mortality rate, but it was less dangerous because it had a far shorter incubation time and was much less transmissible.

What's really turning the novel coronavirus into a killer is the combination of easy transmission with a long and often times symptom-free incubation time where patients are already being infectious and able to spread the virus. This combination is what makes this thing so tricky. That's why the only solution we have found so far to stop its spread in the long run are economically crippling shutdowns of public life - shutdowns which, here comes the punchline, are economically unsustainable in the long run.

Quote (dro94 @ 21 Apr 2020 22:17)

Uni of Oxford trialling Covid 19 vaccine on humans from Thursday. Is there even a benefit to being first, like can we sell it to other countries or is it handed out to big pharma on a plate to then sell back to us? Bazi give me the lowdown

Selling the vaccine to the EU for a hugely inflated markup to make up our economic losses from covid 19 sounds like an absolutely brilliant plan.

Quote (Djunior @ 21 Apr 2020 23:24)

I'm talking about SARS being dangerous enough to make a vaccine.

Quote (Black XistenZ @ Apr 21 2020 10:26pm)

Reputation for the Uni?

Whoever saves the world from this virus will get huge fame, and most likely a Nobel Prize in medicine.

Quote (Black XistenZ @ Apr 21 2020 11:29pm)

Afaik it was contained before a vaccine was anywhere near the end of its development, so that no one had an incentive to continue working on it anymore.

I guess a virus that is both contained in the present, and also rather easy to contain should it break out again in the future, is just not economically attractive for private labs/companies; and not a top priority for public researchers either.

Quote

Discussion
The emergence of the disease SARS and the rapid identification of its severity and high risk for death prompted a rapid mobilization for control at the major sites of occurrence and at the international level. Part of this response was for development of vaccines for potential use in control, a potential facilitated by the rapid identification of the causative agent, a new coronavirus [8]–[9]. Applying the principles of infection control brought the epidemic under control but a concern for reemergence naturally or a deliberate release supported continuation of a vaccine development effort so as to have the knowledge and capability necessary for preparing and using an effective vaccine should a need arise. For this purpose, the National Institute of Allergy and Infectious Diseases supported preparation of vaccines for evaluation for potential use in humans. This effort was hampered by the occurrence in the initial preclinical trial of an immunopathogenic-type lung disease among ferrets and Cynomolgus monkeys given a whole virus vaccine adjuvanted with alum and challenged with infectious SARS-CoV [14]. That lung disease exhibited the characteristics of a Th2-type immunopathology with eosinophils in the lung sections suggesting hypersensitivity that was reminiscent of the descriptions of the Th2-type immunopathologic reaction in young children given an inactivated RSV vaccine and subsequently infected with naturally-occurring RSV [32]–[33]. Most of these children experienced severe disease with infection that led to a high frequency of hospitalizations; two children died from the infection [33], [40], [41]. The conclusion from that experience was clear; RSV lung disease was enhanced by the prior vaccination. Subsequent studies in animal models that are thought to mimic the human experience indicate RSV inactivated vaccine induces an increased CD4+ T lymphocyte response, primarily of Th2 cells and the occurrence of immune complex depositions in lung tissues [32], [42], [43]. This type of tissue response is associated with an increase in type 2 cytokines including IL4, IL5, and IL13 and an influx of eosinophils into the infected lung; [32], [33], [42], [44]. Histologic sections of tissues exhibiting this type of response have a notable eosinophilic component in the cellular infiltrates. Recent studies indicate that the Th2-type immune response has both innate and adaptive immune response components [33], [43].