d2jsp
Log InRegister
d2jsp Forums > Off-Topic > General Chat > Political & Religious Debate > Coronavirus Thread
Prev1371372373374375910Next
Add Reply New Topic New Poll
Member
Posts: 54,196
Joined: May 26 2005
Gold: 4,945.67
Apr 10 2020 11:17am
Quote (Thor123422 @ 10 Apr 2020 18:48)
I listened to a video yesterday explaining how like 65% of our cultivated crops are from North America, and how the potato's stability, greater calorie count, and ability to grow in places other plants couldn't was the reason why famines went from once every 2-3 years to once every decade or more in Europe, and effectively lead to the dominance of Northern Europe over the Mediterranean. Basically the reason Rome and Greece were so powerful is because they were situated in areas where crop failures were more rare and so they could support larger populations, whereas Northern Europe had a crop failure every 2-3 years which resulted in significant mortality.


This was mostly a result of the different climate at the time.

In ancient times, Egypt, Northern Africa, Italy, Greece and the Levant were super green and fertile and had more reliable rainfall, while the areas north of the Alps were colder and thus less fertile than they are today.
Over the centuries, Egypt, Northern Africa and the Middle East suffered from desertification which was the main long-term cause of the decline of those empires, while the climate became more favorable in Middle and Northern Europe and fueled the rise of these civilizations.

By the time potatoes were introduced in Europe, the center of European civilization had already shifted north, from being centered around the Mediterranean to being centered around the Alps.
Member
Posts: 66,666
Joined: May 17 2005
Gold: 17,384.69
Apr 10 2020 12:55pm
About twenty people are buried here every day. Nicknamed the Isle of the Dead, Hart Island, north of Manhattan, has housed the bodies of those whom no one claims since the 19th century: the homeless or the destitute who cannot afford a funeral.


Member
Posts: 105,152
Joined: Apr 25 2006
Gold: 10,475.00
Apr 10 2020 02:17pm
Quote (Saucisson6000 @ Apr 10 2020 02:55pm)
About twenty people are buried here every day. Nicknamed the Isle of the Dead, Hart Island, north of Manhattan, has housed the bodies of those whom no one claims since the 19th century: the homeless or the destitute who cannot afford a funeral.


https://bilder.t-online.de/b/87/68/71/26/id_87687126/tid_da/ein-massengrab-auf-hart-island-bei-new-york-hier-beerdigt-die-stadt-offenbar-auch-corona-tote-.jpg




Yeah, you're right, we should probably bury those people in.... farmland?
Member
Posts: 93,005
Joined: Dec 31 2007
Gold: 2,214.94
Apr 10 2020 02:21pm
Quote (Ghot @ Apr 10 2020 03:17pm)
Yeah, you're right, we should probably bury those people in.... farmland?


his post doesn't even contain an opinion
Member
Posts: 40,248
Joined: Feb 14 2007
Gold: 5,737.99
Apr 10 2020 02:27pm
Quote (thesnipa @ Apr 10 2020 03:21pm)
his post doesn't even contain an opinion

lol
Member
Posts: 105,152
Joined: Apr 25 2006
Gold: 10,475.00
Apr 10 2020 02:35pm
Quote (thesnipa @ Apr 10 2020 04:21pm)
his post doesn't even contain an opinion




LOL. Where have YOU been. All his posts are chock full of opinion.





/e









Quarantine mission #1...









This post was edited by Ghot on Apr 10 2020 02:41pm
Member
Posts: 14,099
Joined: Jul 13 2006
Gold: 83.30
Apr 10 2020 02:39pm
Interesting research coming from Radboud UMC in the Netherlands: https://www.preprints.org/manuscript/202004.0023/v1

Quote
Most striking observations in COVID-19 patients are the hints on pulmonary edema (also seen on CT scans as ground glass opacities), dry cough, fluid restrictions to prevent more severe hypoxia, the huge PEEP that is needed while lungs are compliant, and the fact that anti-inflammatory therapies are not powerful enough to counter the severity of the disease. We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on endothelial cells in the lungs. SARS-CoV-2 enters the cell via ACE2, a cell membrane bound molecule with enzymatic activity that next to its role in RAS is needed to inactivate des-Arg9 bradykinin, the potent ligand of the bradykinin receptor type 1 (B1). In contrast to bradykinin receptor 2 (B2), the B1 receptor on endothelial cells is upregulated by proinflammatory cytokines. Without ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to angioedema. Angioedema is likely a feature already early in disease, and might explain the typical CT scans and the feeling of people that they drown. In some patients, this is followed by a clinical worsening of disease around day 9 due to the formation antibodies directed against the spike (S)-antigen of the corona-virus that binds to ACE2 that could contribute to disease by enhancement of local immune cell influx and proinflammatory cytokines leading to damage. In parallel, inflammation induces more B1 expression, and possibly via antibody-dependent enhancement of viral infection leading to continued ACE2 dysfunction in the lung because of persistence of the virus. In this viewpoint we propose that a bradykinin-dependent local lung angioedema via B1 and B2 receptors is an important feature of COVID-19, resulting in a very high number of ICU admissions. We propose that blocking the B1 and B2 receptors might have an ameliorating effect on disease caused by COVID-19. This kinin-dependent pulmonary edema is resistant to corticosteroids or adrenaline and should be targeted as long as the virus is present. In addition, this pathway might indirectly be responsive to anti-inflammatory agents or neutralizing strategies for the anti-S-antibody induced effects, but by itself is likely to be insufficient to reverse all the pulmonary edema. Moreover, we provide a suggestion of how to ventilate in the ICU in the context of this hypothesis.


tl;dr: The coronavirus enters the cell through ACE2, similary to SARS. ACE2 normally inhibits bradykinin. Bradykinin is responsible for vascular leaking. Researchers are now setting up a trial to treat with icatibant, which inhibits bradykinin.

Member
Posts: 66,666
Joined: May 17 2005
Gold: 17,384.69
Apr 10 2020 03:26pm
Quote (Ghot @ 10 Apr 2020 22:17)
Yeah, you're right, we should probably bury those people in.... farmland?


cmon im just posting cool stuff
Member
Posts: 105,152
Joined: Apr 25 2006
Gold: 10,475.00
Apr 10 2020 03:36pm
Quote (Saucisson6000 @ Apr 10 2020 05:26pm)
cmon im just posting cool stuff




The day you post "cool stuff" without that little... twist, I'll probably drop dead from shock. :)








This post was edited by Ghot on Apr 10 2020 03:38pm
Member
Posts: 66,666
Joined: May 17 2005
Gold: 17,384.69
Apr 10 2020 03:40pm
Quote (Ghot @ 10 Apr 2020 23:36)
The day you post "cool stuff" without that little... twist, I'll probably drop dead from shock. :)






http://www.youtube.com/watch?v=d7-UcdcK4AA


What is this crap ?



This post was edited by Saucisson6000 on Apr 10 2020 03:41pm
Go Back To Political & Religious Debate Topic List
Prev1371372373374375910Next
Add Reply New Topic New Poll