Quote (IceMage @ Dec 14 2020 10:07pm)
Actually maybe this thread could be a learning opportunity.
Thor, Bazi, not sure if anyone else applies, why should we be more afraid(or perhaps not) of this vaccine compared to others? Is the speed something to be concerned about? From what I've read they just figured out how to do the vaccine differently from what they've done in the past, but please educate us.
Speed not something to be concerned about. The phases that were expedited were earlier phases, and we know why they were expedited. Phase 3 was the usual length and also a much more powered phase 3 than many FDA approved drugs
Think we have beaten mrna vaccine to death now but it’s different in that the target antigen is an mrna sequence vs a traditional protein antigen. We have never needed to produce a vaccine to the “common cold family” and a traditional protein antigen vaccine would become obsolete after 1 season due to high genetic drift rates common to the coronavirus family. Mrna vaccine offers more specificity especially when it comes to antigen drift. More expensive to produce , more expensive to maintain, never an incentive to do it prior to global $$$
Repost of my DF post so don’t have to retype
Quote
Objectively this is one of the largest phase 3 trials that has ever been performed. Also objectively there are 2-3 companies (3rd company with a slightly inferior vaccine at 75% effectiveness) that have all managed to create a product. There are no significant differences between the pfizer and moderna vaccinations, which isn’t too surprising because they used very similar mechanisms to develop them. Between these two companies, phase 3 had over 50,000 participants which is a very high powered trial.
Everyone needs to understand their personal relative risk. People think they have less risk than they actually do. As a realistic estimate, 60% of America has at least one comorbidity. This is a conservative number. People obsess about mortality rates but the reality is that’s not the major problem. The problem is the hospitalization rate and it isn’t a negligible number.
Medical related bankruptcy is the single highest reason for bankruptcy in the middle class, before covid. currently estimate, 1 in 7 families CURRENTLY have a family member that has been hospitalized from covid. The financial burden of that is serious especially in the climate of many unfortunate people losing insurance through jobs.
If you are a high risk person it’s almost a given you will be able to receive the vaccination earlier, and pros/benefits are much more clear at that risk level. Everything in medicine is just risk stratification.
If you are Medium risk, you make up the demographic that is most likely to be hospitalized, and most likely to benefit from the vaccination. As I stated above , 60% of the population is in this category or higher
If you are low risk, you have a less likelihood of getting hospitalized - fact. Mortality rate is also negligible here - fact. This demographic is also the demographic that has the highest rate of spread to other low risk and also to medium risk individuals. The benefit of this demographic getting the vaccination is to protect the 60% demographic that has a much higher risk of hospitalization and worsened mortality statistics (in addition to protection to inevitable low risk individuals that will get sick and need hospitalization)
I understand the question mark about receiving the vaccine if you are low risk. I especially understand the reservation if you had covid and you are low risk. I would say this, you don’t need to make a decision now, but be open minded. You realistically have time before you need to make a decision on it anyway and you can use the 50,000 phase 3 test subjects and people across the world now receiving it as Guinea pigs so to speak to help with your decision. If you already got covid19 I especially understand the reservation.
Let me repost why I am getting it despite already having covid:
Quote (Bazi @ Dec 12 2020 10:17pm)
antibodies last ~6 months, from what we can currently tell. Reinfections happen but tend to be more benign. However your 2nd benign infection can still be passed to someone else for their first time. Plus the vaccine has been thought to convey longer lasting immunity benefit
From an individual standpoint if you got the virus within 6 months don’t think there is a need to rush to get the vaccine. In fact if you got it within 90 days, depending on where you live, you may be ineligible for the vaccine due to amount of supply.
However the point of the vaccine, like any major vaccine, is largely to protect others as well as yourself. There will be a portion of the population susceptible but whom cannot themselves take the vaccination. Personally for me I drop supplies off for my grandparents. although I maintain distance I would feel more comfortable knowing I have an added bit of protection, for them. Additionally my wife is preg so she won’t be getting the vaccine, and it’s to do my part to protect her. Conveniently I am right at the 6montj point
This post was edited by Bazi on Dec 15 2020 12:03am
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