Ty I can't falter when winter comes in earnest

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This post was edited by JessiWan on Dec 10 2023 05:16pm

Yep

I’m not saying it should be free necessarily because it is a costly and labor intensive process. But the 3 million price tag is something the 100k sicklers in the US cannot afford

The genetics with sickle cell, and specifically hemoglobin, are just really well understood. This is why the cancer risk here is pretty benign in comparison to other disease processes

I don't think its a sickle cell intrinsic thing for cancer risk? It's more the method they're using for gene correction. Bluebird's sickle cell treatment got blackboxed for cancer. Since they're doing all editing ex vivo it sounds like they NGS for any potential risky off-targets before putting the cells back in.

Vertex's treatment is wild tho, as someone who has dabbled in gene editing in the lab I can't image the scale you need to replace a person's bone marrow.

This post was edited by Sioux on Dec 10 2023 05:24pm

Yeah you are definitely right, the mechanism matters

I was just trying to say well defined genotype /phenotype relationships are generally going to have less cancer risk

Considering the level of understanding you've demonstrated on scientific topics in general, I'd say you shouldn't rely on your understanding of statistical mechanics.

Even if CRISPR never makes it to patients it's still revolutionized how gene research is done. Truly a great advancement.



"I mastered out because of antisemitism" - Translated means - "I failed out and need an excuse to blame it on".

Take personal responsibilty for your failings.

I think as long as they get the right stem cells (BIIIIIG IF) then the marrow will re-grow after and propagate to the rest of the relavent bone cavities. So theoretically, they don't need that much successful bone marrow to transplan. Just to keep the patient in isolation for several months.

Lmao Netflix. Why do you fight with everyone.

When somebody has shown themselves to not have anything of value to offer, the only thing that's left is poking fun at them. Which is very fun.

CRISPR, not including hypothetical CRISPR therapy, is a great invention for gene research no doubt. Nobel-prize worthy, much like Electrospray ionization which revolutionized small and large molecule analysis. But neither are scientifically groundbreaking towards our understanding of natural law - both of them are however great inventions.

The only failing would be to waste an additional 3 years of my valuable time learning nothing while being paid less than nothing (even the highest level scholarship, awarded to 1 candidate, pays the equivalent of 25 dollars per hour) getting a degree that serves no purpose other than a presentable token in certain positions to appease clients.

The only reason I would do a PhD is if a company will pay me my full salary to do it. Otherwise, one is a total fool to do a PhD without drawing a proper salary. In fact, the vast majority of PhD graduates are fools who go on to have no ROI for their 4 years of slavery that they wouldn't have with just an MSc.

To add I'm not from America where MScs don't functionally exist stand-alone. I never declared to do a PhD. Then again we also don't have as big of a problem with PhD students killing themselves en-masse, wonder why

This post was edited by El1te on Dec 10 2023 08:19pm