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Dec 24 2021 07:25pm
Quote (Sioux @ Dec 25 2021 02:13am)
So you know literally nothing about how the process works in the US or in your home country, know nothing about how the studies are designed, or anything else at all yet you feel comfortable holding a strong, false opinion?


Lol... I just admit that i don't know the details, which everyone i ask - like you, who claim to know the details - specific details - usually come to show they can't answer the questions i have in detail either - and are only pretending to know a bunch they in all honesty don't. I always try to look into things and educate myself but in the medical industry it is a lot of hush hush, and trust us you don't need to know exactly how we do things - leave that to us experts.

If you can show me where I can read well documented explanations - e v e r y t h i n g about say the placebo safety studies made on these vaccines. Be my guest, give me the details.

What people, what studies before people, on animals i assume,.and the details of those.

exactly how were they made,
How many, what age groups, physical conditions,.BMI, amounts of vaccine, their diet the past week or so, and other values, etc etc etc(!) Everything! And how many times, and fuck i have really a ton of questions about it, like i could probably make a full page of questions i would like to know of big pharmas placebo studies alone, but that's just me..

People like ..others, on the other hand just seem to know everything and are very secret about it, seem to know the secrets but are too..what, too clever to share..? Like the mainstream media "educating us" of how safe the vaccines are, our health organisations too, but their info they give out is a fucking joke with more holes than not.

They have "educated us" for two years and presented numbers and statistics but fail to be clear of many variables of them which is.. a sleeping pill. Looks like trickery.

Did I mention i want details,.preferably with video documentation as well as on paper and everything relevant about the control group, the size of the control group and how many times it was done and just full info..

Even flipping a coin sometimes gets 7-8 heads in a row... if they get a good result in placebo studies, are they immediately satisfied then?

If they don't, do they make some.minor insignificant change and go again, and just make some tests that they may have a lucky coinflip on, and say hey, we did it! I'm tired but i think u get the point..

There are a lot of medicine out there with effects that are slim at best. Like that song what's it called.." the ones that your mother gives you, don't do anything at all"

This post was edited by TidsL on Dec 24 2021 07:46pm
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Dec 24 2021 07:26pm
Quote (TidsL @ Dec 24 2021 05:25pm)
Lol... I just admit that i don't know the details, which everyone i ask - like you, who claim to know the details - specific details - usually come to show they can't answer the questions i have in detail either - and are only pretending to know a bunch they in all honesty don't.


So ask a question. I promise you I understand better than 95% of people on here
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Dec 24 2021 07:40pm
Quote (Sioux @ Dec 25 2021 02:26am)
So ask a question. I promise you I understand better than 95% of people on here


Good to hear, i am too tired now but you can show me some place to read up if you want. Begin with placebo studies in these vaccines.

And then i can come back with questions or if i see things in the methods of placebo studies that remains unclear or doubtful, ( set and setting, expectations and knowledge or lack of, state of mind will affect results too. Mind, belief and expectations can both heal and change some things up in another direction. of course all the exact variables are difficult to pinpoint in the amount of detail i would want.. which is why I'm interested in exactly how these are done and the process, how many people, what people, and how many times they're made before a pharma company considers it done. What is enough info for them in a study so to speak for it to satisfy them.) really I'd just like to learn more simply put.

This post was edited by TidsL on Dec 24 2021 07:48pm
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Dec 24 2021 07:47pm
A friend called him “pet semetary trump”

He could have been the emperor of mankind but he threw it all away
Maybe by design? Maybe they paid him off, maybe they have his family, maybe hes dead and hes just a deep fake...
Who knows? Better to focus on reality moving forward

Looking back 99% of trump was pure meme, what we wanted or hoped, he never said he would do any of it

Fooled me too
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Dec 24 2021 07:50pm
Quote (TidsL @ Dec 24 2021 05:40pm)
Good to hear, i am too tired now but you can show me some place to read up if you want. Begin with placebo studies in these vaccines.

And then i can come back with questions or if i see things in the methods of placebo studies that remains unclear or doubtful, ( set and setting, expectations and knowledge or lack of, state of mind will affect results too. Mind, belief and expectations can both heal and mess some things up.. which is why I'm interested in exactly how these are done and the process) really I'd just like to learn more simply put.


Here's the original vaccine study for Pfizer. https://www.nejm.org/doi/full/10.1056/nejmoa2034577
Here's the orignal study for Moderna https://www.nejm.org/doi/full/10.1056/nejmoa2035389

The methods are written in pretty easy-to-understand English as its a NEJM article and they're usually written for the general, educated scientific population. You're right that state of mind/expectations are a large confound for medical treatments, which is why a double-blind placebo study is considered the gold standard for assessing treatment efficacy. Neither the patient nor the medical staff knows what treatment the patient is given. As an aside, the placebo effect is real but less likely in the case of infectious disease. It's a well-established phenomenon in the pain field, but there isn't a ton of evidence that people can will themselves out of catching a transmissible illness. It's more likely you'll run into nocebo effect which is the inverse where you think you've been given a new treatment and are more likely to experience negative side effects.

Edit: For further transparency, companies that run clinical trials in the US have to preregister their studies on clinicaltrials.gov where they prestate the analysis/trial design so they can't change things as results unfold. If it isn't preregistered, the FDA won't accept the drug application.

Here's Pfzier https://clinicaltrials.gov/ct2/show/NCT04368728
Here's moderna https://clinicaltrials.gov/ct2/show/NCT04470427


I see your giant edit so I'll break it down for you. I'm only going to find the Pfizer data to halve the work but I promise you the Moderna data exists too.
Quote (TidsL @ Dec 24 2021 05:25pm)
exactly how were they made,

Honestly rough details exist but the actual specs are proprietary which is not unusual for drug manufacturing. The short version is they use bioreactors to generate large amounts of plasmids containing the gene for the Covid19 spike protein. These plasmids are isolated using a gigaprep or whatever is one step up from giga, sent off for further purification to isolate pure DNA. The spike protein gene is clipped out by molecular scissors, isolated and then they throw it in a vat with an enzyme called a transcription factor that can process DNA into mRNA which gets packaged into the final vaccine.

Quote (TidsL @ Dec 24 2021 05:25pm)
How many, what age groups, physical conditions,.BMI, amounts of vaccine, their diet the past week or so, and other values, etc etc etc(!) Everything! And how many times, and fuck i have really a ton of questions about it, like i could probably make a full page of questions i would like to know of big pharmas placebo studies alone, but that's just me..


This is covered in both the NEJM papers linked above. Diet, probably not but all relavant demographic data is included.

Quote (TidsL @ Dec 24 2021 05:25pm)
Did I mention i want details,.preferably with video documentation as well as on paper and everything relevant about the control group, the size of the control group and how many times it was done and just full info..

Even flipping a coin sometimes gets 7-8 heads in a row... if they get a good result in placebo studies, are they immediately satisfied then?


Yup fair point but already covered in those NEJM papers.

Quote (TidsL @ Dec 24 2021 05:25pm)
If they don't, do they make some.minor insignificant change and go again, and just make some tests that they may have a lucky coinflip on, and say hey, we did it! I'm tired but i think u get the point..

There are a lot of medicine out there with effects that are slim at best. Like that song what's it called.." the ones that your mother gives you, don't do anything at all"


You can search clinicaltrials.gov for other pre-registered vaccine studies for pfizer or moderna. These were the only ones, they didn't just run random stuff through the pipeline until a positive result popped out.

This post was edited by Sioux on Dec 24 2021 08:08pm
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Dec 24 2021 07:53pm
He was always pro vax lol

Libs were the ones antivax before covid
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Dec 24 2021 08:02pm
Quote (Sioux @ Dec 25 2021 02:50am)
Here's the original vaccine study for Pfizer. https://www.nejm.org/doi/full/10.1056/nejmoa2034577
Here's the orignal study for Moderna https://www.nejm.org/doi/full/10.1056/nejmoa2035389

The methods are written in pretty easy-to-understand English as its a NEJM article and they're usually written for the general, educated scientific population. You're right that state of mind/expectations are a large confound for medical treatments, which is why a double-blind placebo study is considered the gold standard for assessing treatment efficacy. Neither the patient nor the medical staff knows what treatment the patient is given. As an aside, the placebo effect is real but less likely in the case of infectious disease. It's a well-established phenomenon in the pain field, but there isn't a ton of evidence that people can will themselves out of catching a transmissible illness. It's more likely you'll run into nocebo effect which is the inverse where you think you've been given a new treatment and are more likely to experience negative side effects.

Edit: For further transparency, companies that run clinical trials in the US have to preregister their studies on clinicaltrials.gov where they prestate the analysis/trial design so they can't change things as results unfold. If it isn't preregistered, the FDA won't accept the drug application.

Here's Pfzier https://clinicaltrials.gov/ct2/show/NCT04368728
Here's moderna https://clinicaltrials.gov/ct2/show/NCT04470427

Cool, thanks..do you work in medicine ?

Anyway i will have a good look & read another day, i said I was gonna go to bed an hour ago..that went well. 😁

This post was edited by TidsL on Dec 24 2021 08:02pm
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Dec 24 2021 08:07pm
Quote (TidsL @ Dec 24 2021 06:02pm)
Cool, thanks..do you work in medicine ?

Anyway i will have a good look & read another day, i said I was gonna go to bed an hour ago..that went well. 😁


I'm medicine adjacent. I'm a PhD cell biologist who researches neurodegenerative disease treatments. I responded to some of your edits as well.
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Dec 24 2021 10:06pm
oh wow, a politician beats on a minority, what a surprise!
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Dec 24 2021 10:10pm
Love how he also brings up how China is clapping the USA's cheeks when it comes to education.

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