Quote (TidsL @ Dec 24 2021 05:40pm)
Good to hear, i am too tired now but you can show me some place to read up if you want. Begin with placebo studies in these vaccines.
And then i can come back with questions or if i see things in the methods of placebo studies that remains unclear or doubtful, ( set and setting, expectations and knowledge or lack of, state of mind will affect results too. Mind, belief and expectations can both heal and mess some things up.. which is why I'm interested in exactly how these are done and the process) really I'd just like to learn more simply put.
Here's the original vaccine study for Pfizer.
https://www.nejm.org/doi/full/10.1056/nejmoa2034577Here's the orignal study for Moderna
https://www.nejm.org/doi/full/10.1056/nejmoa2035389The methods are written in pretty easy-to-understand English as its a NEJM article and they're usually written for the general, educated scientific population. You're right that state of mind/expectations are a large confound for medical treatments, which is why a double-blind placebo study is considered the gold standard for assessing treatment efficacy. Neither the patient nor the medical staff knows what treatment the patient is given. As an aside, the placebo effect is real but less likely in the case of infectious disease. It's a well-established phenomenon in the pain field, but there isn't a ton of evidence that people can will themselves out of catching a transmissible illness. It's more likely you'll run into nocebo effect which is the inverse where you think you've been given a new treatment and are more likely to experience negative side effects.
Edit: For further transparency, companies that run clinical trials in the US have to preregister their studies on clinicaltrials.gov where they prestate the analysis/trial design so they can't change things as results unfold. If it isn't preregistered, the FDA won't accept the drug application.
Here's Pfzier
https://clinicaltrials.gov/ct2/show/NCT04368728Here's moderna
https://clinicaltrials.gov/ct2/show/NCT04470427I see your giant edit so I'll break it down for you. I'm only going to find the Pfizer data to halve the work but I promise you the Moderna data exists too.
Quote (TidsL @ Dec 24 2021 05:25pm)
exactly how were they made,
Honestly rough details exist but the actual specs are proprietary which is not unusual for drug manufacturing. The short version is they use bioreactors to generate large amounts of plasmids containing the gene for the Covid19 spike protein. These plasmids are isolated using a gigaprep or whatever is one step up from giga, sent off for further purification to isolate pure DNA. The spike protein gene is clipped out by molecular scissors, isolated and then they throw it in a vat with an enzyme called a transcription factor that can process DNA into mRNA which gets packaged into the final vaccine.
Quote (TidsL @ Dec 24 2021 05:25pm)
How many, what age groups, physical conditions,.BMI, amounts of vaccine, their diet the past week or so, and other values, etc etc etc(!) Everything! And how many times, and fuck i have really a ton of questions about it, like i could probably make a full page of questions i would like to know of big pharmas placebo studies alone, but that's just me..
This is covered in both the NEJM papers linked above. Diet, probably not but all relavant demographic data is included.
Quote (TidsL @ Dec 24 2021 05:25pm)
Did I mention i want details,.preferably with video documentation as well as on paper and everything relevant about the control group, the size of the control group and how many times it was done and just full info..
Even flipping a coin sometimes gets 7-8 heads in a row... if they get a good result in placebo studies, are they immediately satisfied then?
Yup fair point but already covered in those NEJM papers.
Quote (TidsL @ Dec 24 2021 05:25pm)
If they don't, do they make some.minor insignificant change and go again, and just make some tests that they may have a lucky coinflip on, and say hey, we did it! I'm tired but i think u get the point..
There are a lot of medicine out there with effects that are slim at best. Like that song what's it called.." the ones that your mother gives you, don't do anything at all"
You can search clinicaltrials.gov for other pre-registered vaccine studies for pfizer or moderna. These were the only ones, they didn't just run random stuff through the pipeline until a positive result popped out.
This post was edited by Sioux on Dec 24 2021 08:08pm