here is another one
Author(s): Woodruff PG (Woodruff, Prescott G.)1,2, Ellwanger A (Ellwanger, Almut)1,2, Solon M (Solon, Margaret)3, Cambier CJ (Cambier, Christopher J.)3, Pinkerton KE (Pinkerton, Kent E.)4, Koth LL (Koth, Laura L.)3
Quote
We found that second hand smoke exposure induced a dose-dependent increase in alveolar macrophage recruitment (mean +/- sd; 224,511 +/- 52,330 vs 166,152 +/- 47,989 macrophages/ml of bronchoalveolar lavage in smoke-exposed vs; air-exposed controls at 3 months, p = 0.003). We also found increased expression of several markers of alveolar macrophage activation (PLA2g7, dkfzp434l142, Trem-2, and pirin, all p < 0.01 at 3 months) and increased lavage levels of two inflammatory mediators associated with COPD (CCL2 [MCP-1], 58 +/- 12 vs. 43 +/- 22 pg/ml, p = 0.03; and TNF alpha, 138 +/- 43 vs 88 +/- 78 pg/ml, p = 0.04 at 3 months). These findings indicate that second smoke exposure can cause macrophage recruitment and activation, providing a biological link between second-hand smoke exposure and the development of inflammatory processes linked to COPD.