Sure. The efficacy and risks of vaccines are something that can be studied scientifically over long periods of time, and can provably have high effectiveness with extremely low risks, at which point they should be not just approved but mandatory. Those risks can be more uncertain and higher for new mechanisms of action, and effectiveness lessened against more rapidly mutating and ephemeral diseases, which leaves us unable to establish the requisite evidence to support approving them let alone making them mandatory.
To speak on this subject, I invite the president of the united states of america to give his word;
https://www.bbc.com/news/world-us-canada-55193939