Look at it this way:
Each action has a 1 sec delay when skilling (ALL SKILLS), so within that 1 sec delay, you have to click (KEYWORD click) UNLESS you FORESEE that it will happen again and HOLD down the mouse buttom.
You choose how you want to skill, test this out with Fishing and Cooking, once you get the timing right, you will notice you can come back from a disastrous outcome if you were HOLDING down your mouse button. Oh, this also comes in handy when in a Catacomb / Map run also vs Monster Spawns.