This means you may need to update the bios with another cpu if its from old stock.
Warning!Some AMD B450 chipset motherboards may need a BIOS update prior to using Matisse CPUs. Upgrading the BIOS may require a different CPU that is supported by older BIOS revisions.
This means if you use a m.2 drive in slot #1 2 or usually 6 sata ports are disabled as they share lanes.
Note:The motherboard M.2 slot #1 shares bandwidth with SATA 6.0 Gb/s ports. When the M.2 slot is populated with a PCIe-based M.2 drive, two SATA 6.0 Gb/s ports are disabled.
This means no one from site had verified size dimensions and some cpu coolers or cards won't fit.
Note:Some physical dimension restrictions cannot (yet) be automatically checked, such as cpu cooler / RAM clearance with modules using tall heat spreaders.
Tbh the only one that will potentially be an issue is top one.