u probably have 2x nvme slots allready, which should be enough, given that u can easy add 2TB in those, if not u can use sata ports..
extra pcie slots is pretty much useless imo, use to be for stuff like SLI, wifi, capture card, extra usb ports or other connections..
if u wanna upgrade a prebuild alienware, u should probably check thermals and see if better case/cooling could be improve