"There is evidence that hyperinsulinaemia, hyperglycaemia and chronic inflammation may affect the neoplastic process through various pathways, including the insulin/IGF-1 pathway, and most cancer cells express insulin and IGF-1 receptors. Insulin has been shown to stimulate mitogenesis (even in cells lacking IGF-1 receptors)50 and it may also contribute by stimulating multiple cancer mechanisms, including proliferation, protection from apoptotic stimuli, invasion and metastasis.51"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826507/

Now this does not mean we should necessarily follow the ketogenic diet and stop carbs right away.

We need carbohydrates to survive, plus there is potential for renal damage and hypertension due to excess nitrogen from protein metabolism and sulphur containing amino acids.

There's increasingly growing respect from a variety of oncology societies, I mean all a PET scan comprises of is a radioactive load of glucose.

The long term risk of CKD is physiologically plausible, unfortunately no case control studies to date

Carbohydrates are NOT needed to survive. The brain can utilize ketones at as much as 70% with liver gluconeogenisis covering the rest.

Youre also clueless because ketogenic diet is low-protein

This post was edited by EndlessSky on Oct 30 2017 05:05pm

Im really confused. Urbandictionary has like eight definitions for that word.

They also used that word in the hilarious buzzfeed testosterone article today

Weren't we taught that ketosis is technically a bad thing though?

CKD is the main issue, if all that's being broken down in the body are aminos to the nitrogen/sulfur byproducts, that does not put the body in a healthy state at all...that will wreak havoc on the glomerolui and decrease filtration.

In a healthy person with a balanced diet I don't easily identify the pros and there isn't enough out there yet on the cons. The presumed mechanism for CKD isn't nitrogen/sulfur products but ketones causing tubular dysfunction, not glomerular. All of this is just hypothetical still at present time.

However it's effect on neoplastic cells is very interesting. I would bet that the all you can eat approach to cancer patients will be outdated within the next decade.

Who knew that we don't know shit about food and its effects on the body after centuries of eating, lmao.

In all likelihood problems with this diet will arise as more people try it.

There's always a drawback. Hopefully though it will be less than the carb based diets.

yep, like I said there has been no demonstrated increase in renal impairment with this diet to date, however couple with a significant lack of studies on the matter

I did this all of 2015 and into early 2016. I'm a vegetarian so it was slightly more difficult than the traditional keto diet. Felt great, lost the beer gut, also helped my acid reflux. Could go back on it pretty easily.