I finally reached level 60 cosmic prestige on Black Widow. It's my only cosmic prestige character so it's a nice little accomplishment but I can't imagine being able to do this on every hero. It's a really tough grind to say the least. I'm just now experiencing some of the exciting end-game content that I hadn't before played.
But first, before I consider myself capable of comfortably defeating the tough end-game content, I must upgrade all of my gear and even medallion. A friend in the game hooked me up with some powerful artifacts (four of them that I happily equipped) that I wouldn't have otherwise been able to get myself. So that definitely helped me out a lot.
It's going to take me a while to be as good as I want to become in this game (I still consider myself a newbie 3.5 months in), but I'm slowly but surely getting there. In the mean time I just have to keep saving up my eternity splinters so I can unlock everything I need. Roster expansion most specifically (playable heroes and team-up heroes), but also an extra stash tab that I've been needing. I'll be unlocking the General 38 S.T.A.S.H. tab for 600 eternity splinters once I have that much saved up again. I currently have a little over 300 eternity splinters.