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Nov 19 2015 12:48pm
Quote (Bazi @ Nov 18 2015 06:46pm)
http://mobile.reuters.com/article/idUSKCN0T739620151118

You guys might remember the infected colonoscopy scopes that left them in critical condition and 3 (going from memory) died from, the infection that killed 10+ in a London hospital a short time after that. Both those were due to the ndm1 plasmid that is highly transmissible among gram negative specimens. In short it confers resistance to the vast majority of antibiotics currently on the market (generation 5 cephalosporins having VERY modest success). We worry about the over prescription of antibiotics in America and the repercussions they might have. While this is well and true, we sometimes forget what the rest of the world is doing. Blame of how ndm1 first came on to the scene is still contested but it is consensus that it came from either India or England where antibiotic prescriptions are under far less scrutiny. The Swedish were the first to publish it and it was an Indian patient so they named it ndm1 (New Delhi metalloprotease 1). Regardless of where it came from, it's here now. As far as I'm aware this is the first news I have heard about bacteria harboring this plasmid asymtompatically colonizing a person's flora.

Imo this issue is a very threatening global issue that gets modest press. In short if you become infected with this (more than a carrier state) then there is statistically a 92% chance you will die from it. It's an interesting issue because there isn't a way a single country can protect against it. Like climate change it truly is a global issue. I'll post a figure on when the plasmid first was identified, how it was spread, and how many paitients died per year, but it has increased exponentially over the past 5 years. It is an issue we will hear about more as time passes. I'm uncertain as to how effective the who is, but if they are as ineffective as the UN this will be a huge problem.


This was on tv today.... this is very scary and bad
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Nov 19 2015 12:57pm
Quote (josh2234 @ 19 Nov 2015 19:48)
This was on tv today.... this is very scary and bad


especially since ISIS can put it in pocket, bring it to usa, and drop it in mc donald burgers !

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Nov 19 2015 12:59pm
and then there were zombies
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Nov 19 2015 12:59pm
Quote (Saucisson6000 @ Nov 19 2015 12:57pm)
especially since ISIS can put it in pocket, bring it to usa, and drop it in mc donald burgers !

https://i.ytimg.com/vi/C7y80NYS7p4/maxresdefault.jpg


tbh I don't know whether you really want to debate anymore or just troll people...
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Nov 19 2015 01:00pm
Quote (Saucisson6000 @ Nov 19 2015 01:14pm)
oh ok, so you are saying once a plasmid exist in a population it will never go away ?



They would follow the same rules as other organisms. If the specimens containing the plasmids live, then those plasmids will get continued to be passed on. If environment selects against these organisms then the plasmids contained within do not get passed on.
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Nov 19 2015 01:14pm
Quote (Bazi @ 19 Nov 2015 14:00)
They would follow the same rules as other organisms. If the specimens containing the plasmids live, then those plasmids will get continued to be passed on. If environment selects against these organisms then the plasmids contained within do not get passed on.



So in very simple layman's terms this plasmid will go from bacterial infection to infection basically building or having immunity to any antibodies or rather reducing the antibodies ability to work against any infection. But either way people will be or could be dying from a significant variety of infections
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Nov 19 2015 01:15pm
Quote (Bazi @ 19 Nov 2015 20:00)
They would follow the same rules as other organisms. If the specimens containing the plasmids live, then those plasmids will get continued to be passed on. If environment selects against these organisms then the plasmids contained within do not get passed on.


question: does a plasmid end up being integrated in DNA when its always required for the survival (i guess it is the way it works) ?
has it have been ever observed ? and if yes how much time / generations it takes ? can it be done in laboratory ?
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Nov 19 2015 01:19pm
Quote (Saucisson6000 @ Nov 19 2015 02:15pm)
question: does a plasmid end up being integrated in DNA when its always required for the survival (i guess it is the way it works) ?
has it have been ever observed ? and if yes how much time / generations it takes ? can it be done in laboratory ?



A plasmid is DNA that never becomes integrated in host/bacterial genome. It stays separate, but within the cell.
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Nov 19 2015 01:21pm
Quote (Bazi @ 19 Nov 2015 20:19)
A plasmid is DNA that never becomes integrated in host/bacterial genome. It stays separate, but within the cell.


allright, but then from where is coming the bacteria genome ? only mutations ? virus ?
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Nov 19 2015 01:22pm
Quote (Bazi @ Nov 19 2015 02:19pm)
A plasmid is DNA that never becomes integrated in host/bacterial genome. It stays separate, but within the cell.


...extrachromosomal ...outside of the nucleus .
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