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May 8 2013 03:30pm
Ok, so my autosomal DNA analysis is done and it gave me the following:

7.2% British/Irish
1.4% French/German
37.6% Unspecified Northern European
10.2% Italian
9.1% Unspecified Southern European
33.9% Unspecified European
0.3% East Asian

A couple things to note here. I have a remarkable amount of European DNA in me which clearly screams West Europe. Eastern Europeans tend to have Ashkanazi and Middle Eastern blood.

I was thrown off by the East Asian. I compared my chromosomes to my mom's and I definitely got it from her since we share the same segment on the first chromosome. That segment is found only in people with East Asian ancestry. How did it get there? Well, there are two theories. The first is that I have Native American blood in me. Native Americans and East Asians come from the same supergroup. However, that happened 20K years ago and Native Americans developed their own mutation. It's highly unlikely given that this test is only good for about 500 years of ancestry. The more likely theory is due to the Genghis Khan factor. There are a lot of Europeans with East Asian DNA in them from the conquests and trading.
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May 8 2013 06:52pm
They ought to cut you a check, this topic convinced me to drop $109 on a kit. :thumbsup:
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May 8 2013 08:31pm
Quote (Jp2050 @ May 8 2013 04:52pm)
They ought to cut you a check, this topic convinced me to drop $109 on a kit. :thumbsup:


Nice!

It's totally worth it IMO.

So the ancestry classification in post 21 is with a 70% confidence interval.

Here is what I am with 50% confidence:
22.7% British/Irish
18.7% French/German
23.9% Unspecified Northern European
20.9% Italian
0.4% Iberian
0.2% Balkan
8.4% Unspecified Southern European
4.3% Unspecified European
0.3% East Asian
0.2% Subsaharan African

At 90% confidence, I'm:
0.6% British/Irish
22.6% Unspecified Northern European
3.7% Italian
6.6% Unspecified Southern European
64% Unspecified European
0.3% East Asian
2.1% Unassigned

Now, I compared my chromosomes to my mom's and we definitely share the Subsaharan African segment. It will probably take the system a couple days to adjust the confidence levels now since (the more relatives, the higher the confidence) I linked my profile with her.

HEALTH REPORT
So, here are some of my health risks according to the site (only posting established research...there are 90 things that are still in preliminary research)...only one that's really scary is Alzheimer's
Each condition/disease links to a big explanation on how genetics affects your risk and what not. Anyway, the report is my likelihood %, average European likelihood %, and the multiplication factor.
Without further delay!

Atrial Fibrillation 33.9% 27.2% 1.25x
Prostate Cancer 28.3% 17.8% 1.59x
Alzheimer's Disease 14.2% 7.2% 1.98x
Restless Legs Syndrome 2.5% 2.0% 1.25x
Multiple Sclerosis 0.93% 0.34% 2.72x
Age-related Macular Degeneration 4.4% 6.5% 0.67x
Melanoma 2.2% 2.9% 0.75x
Rheumatoid Arthritis 1.5% 2.4% 0.63x
Parkinson's Disease 1.2% 1.6% 0.74x
Exfoliation Glaucoma 0.60% 0.75% 0.79x
Esophageal Squamous Cell Carcinoma (ESCC) 0.29% 0.36% 0.80x
Type 1 Diabetes 0.27% 1.02% 0.26x
Crohn's Disease 0.21% 0.53% 0.39x
Stomach Cancer (Gastric Cardia Adenocarcinoma) 0.18% 0.23% 0.77x
Primary Biliary Cirrhosis 0.04% 0.08% 0.48x
Celiac Disease 0.04% 0.12% 0.31x Obesity 63.4% 63.9% 0.99x
Coronary Heart Disease 43.4% 46.8% 0.93x
Type 2 Diabetes 22.1% 25.7% 0.86x
Venous Thromboembolism 12.8% 12.3% 1.04x
Psoriasis 9.9% 11.4% 0.87x
Lung Cancer 8.2% 8.5% 0.97x
Gallstones 6.2% 7.0% 0.88x
Colorectal Cancer 4.9% 5.6% 0.89x
Chronic Kidney Disease 3.6% 3.4% 1.04x
Ulcerative Colitis 0.83% 0.77% 1.09x
Bipolar Disorder 0.10% 0.10% 0.94x
Scleroderma (Limited Cutaneous Type) 0.05% 0.07% 0.80x
Breast Cancer 0.00% 0.00% 1.00x
Lupus (Systemic Lupus Erythematosus) 0.00% 0.00% 1.00x

This post was edited by thundercock on May 8 2013 08:32pm
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May 8 2013 08:42pm
Inherited Conditions
It seems that I'm a weak carrier for Hemochromatosis...everything else is peachy though!
Hemochromatosis (HFE-related) Variant Present
Alpha-1 Antitrypsin Deficiency Variant Absent
Agenesis of the Corpus Callosum with Peripheral Neuropathy (ACCPN) Variant Absent
Autosomal Recessive Polycystic Kidney Disease Variant Absent
ARSACS Variant Absent
Beta Thalassemia Variant Absent
Bloom's Syndrome Variant Absent
BRCA Cancer Mutations (Selected) Variant Absent
Canavan Disease Variant Absent
Congenital Disorder of Glycosylation Type 1a (PMM2-CDG) Variant Absent
Cystic Fibrosis Variant Absent
D-Bifunctional Protein Deficiency Variant Absent
Dihydrolipoamide Dehydrogenase Deficiency Variant Absent
DPD Deficiency Variant Absent
Familial Dysautonomia Variant Absent
Factor XI Deficiency Variant Absent
Fanconi Anemia (FANCC-related) Variant Absent
Familial Hypercholesterolemia Type B Variant Absent
Familial Hyperinsulinism (ABCC8-related) Variant Absent
Familial Mediterranean Fever Variant Absent
Hereditary Fructose Intolerance Variant Absent
G6PD Deficiency Variant Absent
Gaucher Disease Variant Absent
GRACILE Syndrome Variant Absent
Glycogen Storage Disease Type 1a Variant Absent
Glycogen Storage Disease Type 1b Variant Absent
Primary Hyperoxaluria Type 2 (PH2) Variant Absent
Hypertrophic Cardiomyopathy (MYBPC3 25bp-deletion) Variant Absent
LAMB3-related Junctional Epidermolysis Bullosa Variant Absent
Leigh Syndrome, French Canadian Type (LSFC) Variant Absent
Maple Syrup Urine Disease Type 1B Variant Absent
Mucolipidosis IV Variant Absent
Neuronal Ceroid Lipofuscinosis (CLN5-related) Variant Absent
Neuronal Ceroid Lipofuscinosis (PPT1-related) Variant Absent
Niemann-Pick Disease Type A Variant Absent
Nijmegen Breakage Syndrome Variant Absent
Connexin 26-Related Sensorineural Hearing Loss Variant Absent
Pendred Syndrome Variant Absent
Phenylketonuria Variant Absent
Rhizomelic Chondrodysplasia Punctata Type 1 (RCDP1) Variant Absent
Salla Disease Variant Absent
Sickle Cell Anemia & Malaria Resistance Variant Absent
Tay-Sachs Disease Variant Absent
Torsion Dystonia Variant Absent
TTR-Related Cardiac Amyloidosis Variant Absent
TTR-Related Familial Amyloid Polyneuropathy Variant Absent
Tyrosinemia Type I Variant Absent
Zellweger Syndrome Spectrum Variant Absent
Limb-girdle Muscular Dystrophy No Data
Medium-Chain Acyl-CoA Dehydrogenase (MCAD) Deficiency No Data
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Posts: 35,291
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Gold: 12,730.67
May 8 2013 08:50pm
Drug Response
Clopidogrel (Plavix®) Efficacy Reduced
Warfarin (Coumadin®) Sensitivity Increased
Abacavir Hypersensitivity Typical
Alcohol Consumption, Smoking and Risk of Esophageal Cancer Typical
Fluorouracil Toxicity Typical
Response to Hepatitis C Treatment Typical
Pseudocholinesterase Deficiency Typical
Thiopurine Methyltransferase Deficiency Typical
Oral Contraceptives, Hormone Replacement Therapy and Risk of Venous Thromboembolism Not Applicable
Caffeine Metabolism Fast Metabolizer

Fun Traits
It seems like that I'm resistant to the stomach flu, have wet earwax, and am more likely to develop a smoking addiction. In addition, I can smell asparagus in people's urine!

The nice thing is, your data keeps updating as more research is done. Pretty cool concept.

This post was edited by thundercock on May 8 2013 08:55pm
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May 9 2013 02:22pm
Quote (thundercock @ May 9 2013 02:31am)
Nice!

It's totally worth it IMO.

So the ancestry classification in post 21 is with a 70% confidence interval.

Here is what I am with 50% confidence:
22.7% British/Irish
18.7% French/German
23.9% Unspecified Northern European
20.9% Italian
0.4% Iberian
0.2% Balkan
8.4% Unspecified Southern European
4.3% Unspecified European
0.3% East Asian
0.2% Subsaharan African

At 90% confidence, I'm:
0.6% British/Irish
22.6% Unspecified Northern European
3.7% Italian
6.6% Unspecified Southern European
64% Unspecified European
0.3% East Asian
2.1% Unassigned

Now, I compared my chromosomes to my mom's and we definitely share the Subsaharan African segment. It will probably take the system a couple days to adjust the confidence levels now since (the more relatives, the higher the confidence) I linked my profile with her.

HEALTH REPORT
So, here are some of my health risks according to the site (only posting established research...there are 90 things that are still in preliminary research)...only one that's really scary is Alzheimer's
Each condition/disease links to a big explanation on how genetics affects your risk and what not. Anyway, the report is my likelihood %, average European likelihood %, and the multiplication factor.
Without further delay!

Atrial Fibrillation 33.9% 27.2% 1.25x 
Prostate Cancer 28.3% 17.8% 1.59x 
Alzheimer's Disease 14.2% 7.2% 1.98x 
Restless Legs Syndrome 2.5% 2.0% 1.25x 
Multiple Sclerosis 0.93% 0.34% 2.72x 
Age-related Macular Degeneration 4.4% 6.5% 0.67x 
Melanoma 2.2% 2.9% 0.75x 
Rheumatoid Arthritis 1.5% 2.4% 0.63x 
Parkinson's Disease 1.2% 1.6% 0.74x 
Exfoliation Glaucoma 0.60% 0.75% 0.79x 
Esophageal Squamous Cell Carcinoma (ESCC) 0.29% 0.36% 0.80x 
Type 1 Diabetes 0.27% 1.02% 0.26x 
Crohn's Disease 0.21% 0.53% 0.39x 
Stomach Cancer (Gastric Cardia Adenocarcinoma) 0.18% 0.23% 0.77x 
Primary Biliary Cirrhosis 0.04% 0.08% 0.48x 
Celiac Disease 0.04% 0.12% 0.31x Obesity 63.4% 63.9% 0.99x 
Coronary Heart Disease 43.4% 46.8% 0.93x 
Type 2 Diabetes 22.1% 25.7% 0.86x 
Venous Thromboembolism 12.8% 12.3% 1.04x 
Psoriasis 9.9% 11.4% 0.87x 
Lung Cancer 8.2% 8.5% 0.97x 
Gallstones 6.2% 7.0% 0.88x 
Colorectal Cancer 4.9% 5.6% 0.89x 
Chronic Kidney Disease 3.6% 3.4% 1.04x 
Ulcerative Colitis 0.83% 0.77% 1.09x 
Bipolar Disorder 0.10% 0.10% 0.94x 
Scleroderma (Limited Cutaneous Type) 0.05% 0.07% 0.80x 
Breast Cancer 0.00% 0.00% 1.00x 
Lupus (Systemic Lupus Erythematosus) 0.00% 0.00% 1.00x


It definitely ain't lupus!

Fun stuff. How long do they keep updating the data? Indefinitely or is it like a 1-year deal?
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May 9 2013 04:01pm
Quote (balrog66 @ May 9 2013 12:22pm)
It definitely ain't lupus!

Fun stuff. How long do they keep updating the data? Indefinitely or is it like a 1-year deal?


For now it appears to be indefinitely.
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Joined: Nov 29 2008
Gold: 40.64
Jun 5 2013 07:32pm
Quote (thundercock @ May 8 2013 07:31pm)
HEALTH REPORT
Obesity 63.4% 63.9% 0.99x
Coronary Heart Disease 43.4% 46.8% 0.93x

I'm confused by this. These look like 21 century Europe numbers (where those diseases are largely do to current diet and lifestyle choices). What type of data are these % likelihood based on? If its based on the current population, what good does that tell you? how could they possibly determine the coronary heart disease risk of all your ancestors without knowing their diet and lifestyle? I thought that certain genes have statistically shown a reoccurring presence in people with certain diseases and that this is determined by testing people with and without the disease. But those numbers they gave you don't seem to show any of that data at all.

This post was edited by NatureNames on Jun 5 2013 07:40pm
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Gold: 3,188.50
Jun 7 2013 09:28pm
ya im definatly doing this i was waiting for you to post the results
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Jun 15 2013 09:48am
Quote (thundercock @ May 9 2013 02:31am)
Nice!

It's totally worth it IMO.

So the ancestry classification in post 21 is with a 70% confidence interval.

Here is what I am with 50% confidence:
22.7% British/Irish
18.7% French/German
23.9% Unspecified Northern European
20.9% Italian
0.4% Iberian
0.2% Balkan
8.4% Unspecified Southern European
4.3% Unspecified European
0.3% East Asian
0.2% Subsaharan African

At 90% confidence, I'm:
0.6% British/Irish
22.6% Unspecified Northern European
3.7% Italian
6.6% Unspecified Southern European
64% Unspecified European
0.3% East Asian
2.1% Unassigned

Now, I compared my chromosomes to my mom's and we definitely share the Subsaharan African segment. It will probably take the system a couple days to adjust the confidence levels now since (the more relatives, the higher the confidence) I linked my profile with her.

HEALTH REPORT
So, here are some of my health risks according to the site (only posting established research...there are 90 things that are still in preliminary research)...only one that's really scary is Alzheimer's
Each condition/disease links to a big explanation on how genetics affects your risk and what not. Anyway, the report is my likelihood %, average European likelihood %, and the multiplication factor.
Without further delay!

Atrial Fibrillation 33.9% 27.2% 1.25x 
Prostate Cancer 28.3% 17.8% 1.59x 
Alzheimer's Disease 14.2% 7.2% 1.98x 
Restless Legs Syndrome 2.5% 2.0% 1.25x 
Multiple Sclerosis 0.93% 0.34% 2.72x 
Age-related Macular Degeneration 4.4% 6.5% 0.67x 
Melanoma 2.2% 2.9% 0.75x 
Rheumatoid Arthritis 1.5% 2.4% 0.63x 
Parkinson's Disease 1.2% 1.6% 0.74x 
Exfoliation Glaucoma 0.60% 0.75% 0.79x 
Esophageal Squamous Cell Carcinoma (ESCC) 0.29% 0.36% 0.80x 
Type 1 Diabetes 0.27% 1.02% 0.26x 
Crohn's Disease 0.21% 0.53% 0.39x 
Stomach Cancer (Gastric Cardia Adenocarcinoma) 0.18% 0.23% 0.77x 
Primary Biliary Cirrhosis 0.04% 0.08% 0.48x 
Celiac Disease 0.04% 0.12% 0.31x Obesity 63.4% 63.9% 0.99x 
Coronary Heart Disease 43.4% 46.8% 0.93x 
Type 2 Diabetes 22.1% 25.7% 0.86x 
Venous Thromboembolism 12.8% 12.3% 1.04x 
Psoriasis 9.9% 11.4% 0.87x 
Lung Cancer 8.2% 8.5% 0.97x 
Gallstones 6.2% 7.0% 0.88x 
Colorectal Cancer 4.9% 5.6% 0.89x 
Chronic Kidney Disease 3.6% 3.4% 1.04x 
Ulcerative Colitis 0.83% 0.77% 1.09x 
Bipolar Disorder 0.10% 0.10% 0.94x 
Scleroderma (Limited Cutaneous Type) 0.05% 0.07% 0.80x 
Breast Cancer 0.00% 0.00% 1.00x 
Lupus (Systemic Lupus Erythematosus) 0.00% 0.00% 1.00x


from all that information I have some suspicion.

do you take anabolic steroids, or do you have a hightened level of testosterone? muscular build or a thick, fast growing beard?
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