ignore l4d, 4 Ghz should be cake with your setup.

consider your bus speed as an extra multiplier, so weather you go straight multiplier or combo bus speed, it's gonna be the same frequency.
i'd keep your bus speed around 2 and change the multiplier from there, you may run into stability issues with some software in the asus suite not letting you actually deliver the desired voltage to your cpu, that's something you will have to look up though, i don't run an asus board. pretty simply, change it to what you want it at, even with voltage regs, you should be able to hit 4.0Ghz at like 1.35v, without worrying about voltage restrictions from the asus software. then simply dload cpu-z, hw monitor, prime95 , and watch your temps, you don't wanna go over say 65°.

/e for typos

This post was edited by SaintValentine on Dec 18 2011 09:29pm

Good luck with overclocking within Windows!

gtfo

OP, I was being sarcastic...

he reported that.

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This post was edited by SaintValentine on Dec 19 2011 02:29pm

thx that's very useful information.