this should fix it
http://www.pathofexile.com/forum/view-thread/18531

Really wish i could re-bind Shift key

they are working on it. The end result would be that we can bind our skills (and other actions) to any key we want. I get cramp in my hand from trying to push shift and hover above the 1234 keys..haha.

Yeah, Exactly I used to have to have bind on spacebar... thumb is resting on it anyways.

Oh, hi there zedpoo...